- Tšebeliso ea lisebelisoa tsa bongaka
- Tšebeliso ea boenjiniere ba lisele
- Kopo ea ho chesa
- Kopo ea botle
Collagen ke mofuta oa protheine e tšoeu, e opaque, e se nang lekala, e fumanehang haholo letlalong, lesapong, lefufurung, meno, mesifa, li-ligamente le methapo ea mali ea liphoofolo.Ke protheine ea bohlokoa haholo ea sebopeho sa lisele tse hokahaneng, 'me e na le karolo ho ts'ehetsang litho le ho sireletsa' mele.Lilemong tsa morao tjena, ka nts'etsopele ea theknoloji ea ho ntša collagen le lipatlisiso tse tebileng mabapi le sebopeho le thepa ea eona, ts'ebetso ea likokoana-hloko ea collagen hydrolysates le polypeptides e 'nile ea tsejoa butle-butle.Patlisiso le ts'ebeliso ea collagen e se e le sebaka sa lipatlisiso tsa bongaka, lijo, litlolo le liindasteri tse ling.
Collagen ke protheine ea tlhaho ea 'mele.E na le kamano e ntle bakeng sa limolek'hule tsa protheine holim'a letlalo, antigenicity e fokolang, biocompatibility e ntle le polokeho ea biodegradation.E ka senyeha 'me ea kenngoa,' me e na le ho khomarela hantle.Suture ea ho buoa e entsoeng ka collagen ha e na matla a phahameng a tšoanang le a silika ea tlhaho, empa hape e na le monyetla.Ha e sebelisoa, e na le ts'ebetso e ntle ea ho kopanya liplatelete, phello e ntle ea hemostatic, boreleli bo botle le elasticity.Khokahano ea suture ha e lokolohe, lisele tsa 'mele ha li senyehe nakong ea ts'ebetso,' me li na le ho khomarela hantle leqeba.Tlas'a maemo a tloaelehileng, nako e khutšoanyane feela ea khatello e ka finyella phello e khotsofatsang ea hemostatic.Kahoo collagen e ka etsoa phofo, e bataletseng le spongy hemostatic.Ka nako e ts'oanang, ts'ebeliso ea lisebelisoa tsa maiketsetso kapa collagen ka li-substitutes tsa plasma, letlalo la maiketsetso, methapo ea mali ea maiketsetso, ho lokisoa ha masapo le masapo a maiketsetso le bajari ba li-enzyme tse sa sebetseng ke lipatlisiso tse ngata haholo le ts'ebeliso.
Collagen e na le lihlopha tse fapaneng tse sebetsang ka har'a ketane ea eona ea limolek'hule tsa peptide, tse kang hydroxyl, carboxyl le lihlopha tsa amino, tseo ho leng bonolo ho li amohela le ho tlama mefuta e fapaneng ea li-enzyme le lisele ho finyella immobilization.E na le litšobotsi tsa kamano e ntle le li-enzyme le lisele le ho ikamahanya le maemo ho matla.Ho phaella moo, collagen e bonolo ho e sebetsa le ho theha, kahoo collagen e hloekisitsoeng e ka etsoa ka mefuta e mengata e fapaneng ea thepa, e kang lera, tepi, lakane, seponche, lifaha, joalo-joalo, empa ho sebelisoa ha foromo ea membrane ho tlalehoa haholo.Ntle le biodegradability, monyetla oa lisele, biocompatibility le antigenicity e fokolang, lera la collagen le sebelisoa haholo ho biomedicine.E boetse e na le litšobotsi tse latelang: hydrophilicity e matla, matla a phahameng a tsitsipano, morphology e kang derma le sebopeho, le ho kenella hantle metsing le moea.Bioplasticity e laetsoeng ke matla a phahameng a tensile le ductility e tlase;Ka lihlopha tse ngata tse sebetsang, e ka kopanngoa ka nepo ho laola sekhahla sa ho senyeha ha eona.Solubility e fetohang (ho ruruha);E na le phello ea synergistic ha e sebelisoa le likarolo tse ling tsa bioactive.E ka sebelisana le lithethefatsi;Kalafo e amanang le sefapano kapa ea enzymatic ea ho khetholla li-peptide e ka fokotsa antigenicity, e ka arola likokoana-hloko, ea ba le mesebetsi ea 'mele, joalo ka ho kopanya mali le melemo e meng.
Liforomo tsa kopo ea tleliniki ke tharollo ea metsi, gel, granule, seponche le filimi.Ka mokhoa o ts'oanang, libopeho tsena li ka sebelisoa bakeng sa ho lokolloa butle ha lithethefatsi.Lits'ebetso tsa ho lokolloa butle tsa lithethefatsi tsa collagen tse amohetsoeng 'marakeng' me li ntse li tsoela pele ho nts'etsopele li shebane haholo le kalafo ea anti-infection le glaucoma ho ophthalmology, kalafo ea lehae ea khatello ea maikutlo le taolo ea ts'oaetso ho lokisoeng ha maqeba, dysplasia ea cervical ho gynecology le anesthesia ea lehae nakong ea opereishene. , joalo-joalo.
E ajoa haholo liseleng tsohle tsa 'mele oa motho, collagen ke karolo ea bohlokoa liseleng tsohle mme e etsa extracellular matrix (ECM), e leng thepa ea tlhaho ea scaffold ea tlhaho.Ho latela pono ea ts'ebeliso ea bongaka, collagen e sebelisitsoe ho etsa li-scaffolds tse fapaneng tsa boenjiniere ba lisele, joalo ka letlalo, lisele tsa masapo, trachea le scaffolds tsa methapo ea mali.Leha ho le joalo, collagen ka boeona e ka aroloa ka mekhahlelo e 'meli, e leng li-scaffolds tse entsoeng ka collagen e hloekileng le li-scaffold tse entsoeng ka likarolo tse ling.Li-scaffolds tse hloekileng tsa boenjiniere ba collagen li na le melemo ea ho lumellana hantle, ho sebetsa habonolo, polasetiki, 'me li ka khothalletsa ho khomarela lisele le ho ata, empa ho boetse ho na le mefokolo e kang lisebelisoa tse fokolang tsa collagen, tse thata ho bopeha ka metsing, le ho sitoa ho tšehetsa tsosoloso ea lisele. .Taba ea bobeli, lisele tse ncha sebakeng sa tokiso li tla hlahisa mefuta e fapaneng ea li-enzyme, tse tla etsa hydrolyze collagen 'me li lebise ho senyeha ha li-scaffolds, tse ka ntlafatsoang ka ho hokahanya kapa ho kopanya.Li-biomaterials tse thehiloeng ho collagen li 'nile tsa sebelisoa ka katleho lihlahisoa tsa boenjiniere ba lisele tse kang letlalo la maiketsetso, lesapo la maiketsetso, li-graft tsa cartilage le li-catheters tsa methapo.Litšitiso tsa lefufuru li 'nile tsa lokisoa ho sebelisoa li-gel tsa collagen tse kentsoeng ka har'a chondrocyte' me ho entsoe boiteko ba ho kopanya lisele tsa epithelial, endothelial le cornea ho liponche tsa collagen hore li lumellane le lisele tsa cornea.Tse ling li kopanya lisele tsa stem tse tsoang liseleng tse ikemetseng tsa mesenchymal le gel ea collagen ho etsa li-tendon bakeng sa tokiso ea posttendinous.
Sekhomaretsi sa maiketsetso se entsoeng ka lisele tse entsoeng ka mahlahahlaha se entsoeng ka dermis le epithelium e nang le collagen kaha matrix e sebelisoa haholo lits'ebetsong tsa phepelo ea lithethefatsi ka collagen e le karolo ea mantlha, e ka bopang tharollo ea metsi a collagen mefuteng e fapaneng ea lits'ebetso tsa phepelo ea lithethefatsi.Mehlala e kenyelletsa li sireletsang collagen bakeng sa ophthalmology, liponche tsa collagen bakeng sa ho chesa kapa ho sithabela maikutlo, likaroloana tsa ho fana ka protheine, mefuta ea li-gel ea collagen, lisebelisoa tsa taolo bakeng sa phepelo ea lithethefatsi ka letlalo, le nanoparticles bakeng sa phetiso ea liphatsa tsa lefutso.Ntle le moo, e ka sebelisoa e le substrate bakeng sa boenjiniere ba lisele ho kenyelletsa sistimi ea setso sa lisele, lisebelisoa tsa scaffold bakeng sa methapo ea mali ea maiketsetso le li-valve, jj.
Li-grafts tsa letlalo la Autologous e bile tekanyetso ea lefats'e ea ho phekola ho chesa ha tekanyo ea bobeli le ea boraro.Leha ho le joalo, ho bakuli ba cheleng haholo, ho haella ha li-graft tse loketseng tsa letlalo ho fetohile bothata bo tebileng ka ho fetisisa.Batho ba bang ba sebelisitse mekhoa ea bioengineering ho holisa letlalo la lesea liseleng tsa letlalo la lesea.Ho chesa ho fola ka likhato tse fapaneng nakong ea libeke tse 3 ho isa ho likhoeli tse 18, 'me letlalo le sa tsoa hōla le bontša hypertrophy e nyenyane le ho hanyetsa.Ba bang ba ile ba sebelisa synthetic poly-DL-lactate-glycolic acid (PLGA) le collagen ea tlhaho ho hōlisa li-fibroblasts tsa letlalo la motho tse tharo-dimensional, ho bontša hore: Lisele li ile tsa hōla ka potlako holim'a letlooeng la maiketsetso 'me tsa hōla hoo e batlang e le ka nako e le' ngoe ka hare le ka ntle, 'me lisele tse ntseng li ata 'me li hlahisoa. extracellular matrix ba ne ba feta junifomo.Ha likhoele li kenngoa ka morao ho dermal rat, dermal tissue e ile ea hōla ka mor'a libeke tsa 2, 'me lisele tsa epithelial li ile tsa hōla ka mor'a libeke tse 4.
Collagen e ntšoa letlalong la liphoofolo, letlalo ho phaella ho collagen e boetse e na le hyaluronic acid, chondroitin sulfate le proteoglycan tse ling, li na le palo e kholo ea lihlopha tsa polar, ke ntho e mongobo, 'me e na le phello ea ho thibela tyrosine letlalong ho fetoha. melanin, kahoo collagen e na le moisturizing ea tlhaho, whitening, anti-wrinkle, freckle le mesebetsi e meng, e ka sebelisoa haholo lihlahisoa tsa botle.Sebopeho sa lik'hemik'hale tsa Collagen le sebopeho se etsa hore e be motheo oa botle.Collagen e na le sebopeho se ts'oanang le collagen ea letlalo la motho.Ke protheine ea fiber e sa qhibiliheng ka metsing e nang le tsoekere.Limolek'hule tsa eona li ruile palo e kholo ea li-amino acid le lihlopha tsa hydrophilic, 'me e na le ts'ebetso e itseng ea holim'a metsi le ho lumellana hantle.Ka 70% ea mongobo o lekanyelitsoeng, e ka boloka 45% ea boima ba eona.Liteko li bontšitse hore tharollo e hloekileng ea 0.01% collagen e ka etsa lera le letle la ho boloka metsi, le fana ka mongobo oohle oo letlalo le o hlokang.
Ha lilemo li ntse li eketseha, matla a maiketsetso a fibroblast a fokotseha.Haeba letlalo le haelloa ke collagen, likhoele tsa collagen li tla kopanngoa, e leng se tla fella ka ho fokotseha ha li-intercellular mucoglycans.Letlalo le tla lahleheloa ke bonolo, elasticity le khanya, ho fella ka botsofali.Ha e sebelisoa e le ntho e sebetsang ho litlolo, ea ho qetela e ka namela lera le tebileng la letlalo.Tyrosine eo e nang le eona e qothisana lehlokoa le tyrosine letlalong mme e tlama setsing sa catalytic sa tyrosinase, ka hona e thibela tlhahiso ea melanin, e ntlafatsa ts'ebetso ea collagen letlalong, ho boloka mongobo oa stratum corneum le botšepehi ba sebopeho sa fiber. , le ho khothalletsa metabolism ea lisele tsa letlalo.E na le phello e ntle ea moisturizing le moisturizing letlalong.Mathoasong a lilemo tsa bo-1970, bovine collagen bakeng sa ente e ile ea qala ho hlahisoa United States ho tlosa matheba le masoba le ho lokisa maqeba.
Nako ea poso: Jan-04-2023