High-purity shark chondroitin sulfate ke motsoako oa bohlokoa bakeng sa tlhokomelo ea bophelo bo kopanetsoeng
Chondroitin sulfate (CS) ke glycosaminoglycan ea bohlokoa e amanang le liprotheine ho theha proteoglycans.E ajoa ka ho pharaletseng ka har'a matrix a extracellular le holim'a sele ea lisele tsa liphoofolo, 'me ke karolo ea bohlokoa ea li-tissue tse amanang le liphoofolo, tse ngata haholo ka har'a lefufuru.Sebopeho sa motheo sa chondroitin sulfate se thehoa ka ho fapanyetsana ligation ea D-glucuronic acid le N-acetylgalactosamine ka litlamo tsa glycosidic, tse amanang le karolo ea mantlha ea protheine ho theha sebopeho se rarahaneng sa proteoglycan.
E 'ngoe ea tsona ke chondroitin sulfate e entsoeng ka lishaka, e leng ntho e nang le acidic mucopolysaccharide e lokiselitsoeng ho tloha ho lefufuru la shark.E bonahala e le phofo e tšoeu kapa e tšoeu, e se nang monko, tatso e sa nke lehlakore.Chondroitin shark sulfate ke e 'ngoe ea likarolo tse ka sehloohong tsa mammalian connective tissue,' me e fumaneha haholo ka har'a lefufuru, masapo, tendon, ligaments, sarcolemma le marako a methapo ea mali.
E sebetsa e le ho boloka le ho tšehetsa lefufuru la articular.Ho noa ka mokhoa o itekanetseng oa chondroitin sulfate ho ka thusa ho boloka lisele tsa lefufuru, ho fokotsa ho ruruha le bohloko, ho ntlafatsa ho se sebetse ha manonyeletso, le ho ba le tšireletso e phahameng.Hangata e sebelisoa hammoho le glucosamine, motsoako o ntlafatsang haholo bohloko bo itekanetseng ho isa ho o matla ho osteoarthritis le ho susumetsa collagen e ncha le proteoglycans li-chondrocyte.
| Lebitso la Sehlahiswa | Shark Chondroitin Sulfate Soidum |
| Tšimoloho | Tšimoloho ea Shark |
| Maemo a Boleng | USP40 Standard |
| Ponahalo | Phofo e tšoeu ho isa ho e tšoeu |
| Nomoro ea CAS | 9082-07-9 |
| Mokhoa oa tlhahiso | mokhoa oa enzymatic hydrolysis |
| Likahare tsa Protheine | ≥ 90% ka CPC |
| Tahlehelo ka ho Omisa | ≤10% |
| Likahare tsa Protheine | ≤6.0% |
| Mosebetsi | Tšehetso e Kopanetsoeng ea Bophelo bo Botle, Lefufuru le Bophelo ba Marapo |
| Kopo | Litlatsetso tsa lijo ka Letlapa, Capsules, kapa Powder |
| Setifikeiti sa Halal | E, Halal e netefalitsoe |
| Boemo ba GMP | NSF-GMP |
| Setifikeiti sa Bophelo bo Botle | Ee, setifikeiti sa Bophelo bo Botle se teng molemong oa tumello ea moetlo |
| Shelf Life | Likhoeli tse 24 ho tloha letsatsing la tlhahiso |
| Ho paka | 25KG/Drum, Ho Paka ka Hare: Mekotla ea Pepe e Habeli, Ho Paka Kantle: Moqomo oa Pampiri |
| ITEM | TS'ELISO | TEKO MOKHOA |
| Ponahalo | Phofo e tšoeu ea kristale | E bonoang |
| Boitsebiso | Mohlala o tiisa le laeborari ea litšupiso | Ka NIR Spectrometer |
| Sekhahla sa ho monya sa infrared sa sampole se lokela ho bonts'a maxima feela ka bolelele bo lekanang le ba chondroitin sulfate sodium WS. | Ka FTIR Spectrometer | |
| Sebopeho sa li-disaccharides: Karo-karolelano ea karabelo e phahameng ho △DI-4S ho △DI-6S ha e ka tlase ho 1.0 | Enzymatic HPLC | |
| Rotation ea Optical: Kopana le litlhoko tsa ho potoloha ha mahlo, ho potoloha ka ho khetheha litekong tse ikhethileng | Lisebelisoa tsa USP781S | |
| Assay(Odb) | 90%-105% | HPLC |
| Tahlehelo ka ho Omisa | <12% | USP731 |
| Protheine | <6% | USP |
| Ph (1%H2o Tharollo) | 4.0-7.0 | USP791 |
| Phetoho e khethehileng | - 20°~ -30° | Lisebelisoa tsa USP781S |
| Residue On Ingition (Dry Base) | 20%-30% | USP281 |
| Mesaletsa ea Organic Volatile | NMT0.5% | USP467 |
| Sulfate | ≤0.24% | USP221 |
| Chloride | ≤0.5% | USP221 |
| Ho hlaka (5%H2o Tharollo) | <0.35@420nm | USP38 |
| Bohloeki ba Electrophoretic | NMT2.0% | USP726 |
| Moeli oa li-disaccharides tse khethehileng | ＜10% | Enzymatic HPLC |
| Litšepe tse boima | ≤10 PPM | ICP-MS |
| Kakaretso ea Plate Count | ≤1000cfu/g | USP2021 |
| Yeast & Mold | ≤100cfu/g | USP2021 |
| Salmonella | Ho ba sieo | USP2022 |
| E.Coli | Ho ba sieo | USP2022 |
| Staphylococcus Aureus | Ho ba sieo | USP2022 |
| Boholo ba Karolo | Customized ho ea ka requirments hao | Ka Ntlong |
| Boima ba Bongata | >0.55g/ml | Ka Ntlong |
Ntlha ea pele, chondroitin sulfate ke glycosaminoglycan e fumanehang haholo matrix a extracellular ea lisele.Ka lesapo, e fumanoa haholo-holo karolong e ka thōko ea li-chondrocyte 'me ke karolo ea bohlokoa ea matrix a extracellular lefufuru.Ntho ena e thusa lefufuru ho fumana metsi le limatlafatsi, kahoo ho boloka lefufuru le le mongobo le ho reketla, le ho thusa ho boloka mosebetsi o tloaelehileng oa manonyeletso.
Taba ea bobeli, phello ea 'mele ea chondroitin sulfate e bohlokoa haholo bakeng sa lefufuru la articular.E ka tlama limolek'hule tsa metsi, ea kenya limolek'hule tsa metsi ka har'a limolek'hule tsa proteoglycan, ea tiisa lefufuru le ho eketsa bongata ba mokelikeli oa synovial ka har'a motsoako o kopanetsoeng, ho tlotsa le ho tšehetsa lenonyeletso.Ka tsela ena, lenonyeletso le ka fokotsa ho ferekana le tšusumetso ha le sisinyeha, e le hore motsoako o ka tsamaea ka bolokolohi.
Qetellong, chondroitin sulfate e boetse e sebetsa ho boenjiniere ba lisele tsa masapo.Bafuputsi ba lokiselitse li-hydrogel tse entsoeng ka motsoako o thehiloeng ho chondroitin sulfate, e ikemetseng e tlama li-ion tsa inorganic le ho susumetsa masapo a biomineralization, kahoo e matlafatsa matla a ho tsosolosoa ha masapo.Sena se na le ts'ebeliso ea bohlokoa bakeng sa opereishene ea bongaka ea masapo joalo ka ho lokisa sekoli le ho hlomathisa masapo.
1. Khothaletsa bophelo bo botle bo kopanetsoeng: Chondroitin sulfate ke e 'ngoe ea likarolo tse ka sehloohong tsa lefufuru la articular, le ka thusang lefufuru la articular ho boloka elasticity ea lona le metsi, kahoo ho boloka mosebetsi o tloaelehileng oa motsoako.Ka ho tlatsetsa ka chondroitin sulfate, e ka khothalletsa ho lokisoa le ho tsosolosoa ha lefufuru la articular, kahoo e liehisa mokhoa oa ho senyeha ha manonyeletso.
2. Fokotsa bohloko bo kopanetsoeng: chondroitin sulfate e ka fokotsa karabelo ea ho ruruha ka lenonyeletso, ea fokotsa ho tsosoa ha synovium e kopanetsoeng, ebe e fokotsa bohloko bo kopanetsoeng.Sena se na le phello e kholo ea bohloko ho bakuli ba nang le mafu a kopanetsoeng a kang ramatiki.
3. Ntlafatsa ho tsamaea ha manonyeletso: Chondroitin sulfate e ntlafatsa ho tsamaea le ho feto-fetoha ha motsoako ka ho eketsa lubrication ea manonyeletso le ho fokotsa ho ferekana ha motsoako.Sena se etsa hore lenonyeletso le be bonolo haholoanyane nakong ea ho sisinyeha, ho fokotsa tšitiso e bakoang ke ho satalla ha manonyeletso kapa ho sisinyeha ho lekanyelitsoeng.
4. Sireletsa li-articular cartilage: Chondroitin sulfate e ka thibela ho senyeha ha lefufuru la articular, 'me e khothalletsa ho qaptjoa le ho hlahisa li-chondrocyte, e le hore e be le karolo ea ho sireletsa lefufuru la articular.Sena se thusa ho liehisa mokhoa oa ho tsofala ha manonyeletso le ho senyeha.
1. Pholiso ea maqeba le ho lokisa letlalo: Chondroitin sulfate e phetha karolo ea bohlokoa ts'ebetsong ea ho folisa maqeba.E ka khothalletsa ho tsosolosoa le ho lokisoa ha lisele tsa maqeba, ho ntlafatsa elasticity le ho tiea ha letlalo, le ho thusa ho fokotsa ho thehoa ha lebali.Ka hona, chondroitin sulfate e na le lisebelisoa tse ka sebelisoang lits'ebetsong tsa ho buoa, ho chesa kalafo le ho lokisoa ha letlalo.
2. Indasteri ea litlolo: Ka lebaka la thepa ea eona e ntle ea mongobo le phello e khahlanong le botsofali, chondroitin sulfate e boetse e sebelisoa haholo indastering ea litlolo.E ka ekeletsoa lihlahisoa tsa tlhokomelo ea letlalo e le motsoako oa mongobo, ho thusa ho boloka ho leka-lekana ha mongobo oa letlalo le ho ntlafatsa letlalo la elasticity le gloss.Ho phaella moo, chondroitin sulfate e ka boela ea thibela tlhahiso ea li-radicals tsa mahala, ea liehisa mokhoa oa ho tsofala ha letlalo, 'me ea etsa hore letlalo le be le lenyenyane le le phetseng hantle.
3. Boenjiniere ba lithane le meriana ea ho tsosolosa: Lefapheng la boenjiniere ba lisele le meriana ea ho tsosolosa, chondroitin sulfate e sebelisoa e le karolo ea kaho ea lisebelisoa tsa biomimetic stent.E ka kopanngoa le li-biomaterials tse ling ho etsa li-scaffolds tse nang le mehaho le mesebetsi e itseng bakeng sa ho lokisa kapa ho nkela sebaka sa lisele le litho tse senyehileng.Biocompatibility le bioactivity ea chondroitin sulfate e etsa hore e be mokhethoa oa bohlokoa lefapheng la boenjiniere ba lisele.
4. Phello ea Antitumor: Lilemong tsa morao tjena, liphuputso li fumane hore chondroitin sulfate e boetse e na le matla a antitumor.E ka thibela ho qaleha le tsoelo-pele ea tumor ka ho laola kholo, phapang le mekhoa ea apoptotic ea lisele tsa tumor.Le hoja lipatlisiso tse nepahetseng li ntse li le sethaleng sa pele, tebello ea kopo ea chondroitin sulfate tšimong ea anti-tumor e lebeletsoe.
Chondroitin sulfate le glucosamine sulfate hase tsa mofuta o le mong.Ho na le phapang pakeng tsa sebopeho sa bona, tšebeliso le mokhoa oa ts'ebetso.
Chondroitin sulfate ke glycosaminoglycan e nang le mesebetsi e sa tšoaneng ea likokoana-hloko, ho kenyelletsa le liphello tse laolang lipid le tse khahlanong le ho ruruha.E sebelisoa haholo ho phekola lefu la masapo a osteoarthritis 'me e khona ho fokotsa li-mediator tsa ho ruruha le mekhoa ea apoptotic, ha ka nako e le' ngoe e fokotsa tlhahiso ea li-cytokine tsa ho ruruha, iNOS le MMPs.Ho feta moo, chondroitin sulfate e boetse e phetha karolo ea bohlokoa ho sireletsa le ho lokisoa ha lefufuru la articular, ho thusa lefufuru ho hanela khatello ea kelello tlas'a maemo a sa tšoaneng a ho laela ka ho etsa hore lisele li se ke tsa hlola li e-ba teng.
'Me glucosamine sulfate ke motsoako o mong oa bohlokoa, o sebelisoang haholo ho thibela le ho phekola mefuta e sa tšoaneng ea osteoarthritis, e kang lenonyeletso la lengole le hip joint.E sebetsa ho articular cartilage, ka ho susumetsa li-chondrocyte ho hlahisa proteoglycans e nang le sebopeho se tloaelehileng sa polysome, ho ntlafatsa bokhoni ba ho lokisa li-chondrocyte, ho thibela tšenyo ea li-enzyme tse kang collagenase le phospholipase A2, 'me e ka thibela tlhahiso ea li-radicals tsa mahala tsa superoxidized lisele tse senyehileng, kahoo li lieha. ts'ebetso ea pathological ea osteoarthritis le tsoelo-pele ea lefu lena, ho ntlafatsa ts'ebetso ea manonyeletso, ho imolla bohloko.
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